Minor/Significance Unknown. By using this form you agree with the storage and handling of your data by this website. Either decreases levels of the other by inhibition of GI absorption. The following table present normal hemoglobin ranges: There is another equation for iron deficit that can be used to calculate replenishment needs, that of Ganzoni, which takes into account iron stores as well and that can be found in the iron deficit calculator. Applies only to oral form of both agents. Ferrlecit may be diluted in 100 mL of 0.9% sodium chloride administered by intravenous infusion over 1 hour per dialysis session. A maximum dose of 1000 mg iron can be delivered intravenously over 15 minutes, which may make it a suitable treatment for iron-deficiency anaemia outside of the hospital setting. By entering this website, you acknowledge that you are a licensed healthcare professional practicing in the United States. Avoid or Use Alternate Drug. J Lab Clin Med; 111(5):566-70. MISSED DOSE: It is important to get each dose of this medication as scheduled. Hanson DB, Hendeles L. Guide to total dose intravenous iron dextran therapy. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. Get in touch with MDApp by using the following contact details: 2017 - 2023 MDApp. Minor/Significance Unknown. Monitor Closely (1)iron sucrose decreases levels of levothyroxine by inhibition of GI absorption. Diluted with 0.9% Sodium Chloride Injection at concentrations of 1 to 2 mg/mL, 2 doses of 300 mg/250 mL over 1.5 hrsplus1 dose of 400 mg/250 mL over 2.5 hrs. FOR PATIENTS WEIGHING LESS THAN 50 kg: Administer Monoferric as 20 mg/kg actual body weight by intravenous infusion 20 minutes . Pain, swelling, or redness at the injection site may occur. 1998 Feb;25(1):65-8. Do not double the dose to catch up. STORAGE: Consult the product instructions and your pharmacist for storage details. It is important to note that the above calculations merely provide estimates and that individual dosage should be established by a medical professional based on the current package insert for the elemental iron product used. calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. Volume of iron sucrose needed = 60 x (14 - 8) x (2.145) 20 = 38.6 mL . Applies only to oral form of both agents. Applies only to oral form of both agents. The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. Iron replenishment can be done intravenously, either as total dose (example: iron-dextran or iron carboxymaltose) or as split dose (example: iron sucrose). This document does not contain all possible drug interactions. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hgb conc. Applies only to oral form of both agents. Monitor Closely (1)deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. Interaction only with oral iron administration. 1) Ganzoni AM. Monitor Closely (1)dexlansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. This information is not individual medical advice and does not substitute for the advice of your health care professional. Applies only to oral form of both agents. Minor (2)calcium citrate decreases levels of iron sucrose by inhibition of GI absorption. The dosing for iron replacement treatment in pediatric patients with hemodialysis-dependent chronic kidney disease (HDD-CKD), non-dialysis-dependent chronic kidney disease (NDD-CKD) or peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD) has not been established. All Rights Reserved. Where C= concentration of Discuss the risks and benefits with your doctor.This medication passes into breast milk. Most studies have used IV iron sucrose (maximum dose of 200 mg per setting) or ferric carboxymaltose (maximum dose of 1000 mg per week). Minor/Significance Unknown.iron sucrose increases levels of calcium carbonate by enhancing GI absorption. iron sucrose decreases levels of oxytetracycline by inhibition of GI absorption. IV iron sucrose (Venofer) given as divided dosages, and low molecular weight iron dextran (CosmoFer) this can be given as divided dose or as a total dose infusion . UpToDate. Avoid or Use Alternate Drug. Serious - Use Alternative (1)iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. Serious - Use Alternative (1)iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. Reference www.medicines.org.uk Background Pregnancy: Risk Summary-Clinical Considerations. The dosing for iron replacement treatment in pediatric patients with Peritoneal or Hemodialysis-Dependent - CKD or Non-Dialysis Dependent CKD have not been established. Intravenous (IV) iron products (use in adults) Dosing information in this table is for adults and includes some dosing recommendations not listed in the approved product information. Applies only to oral form of both agents. Monitor Closely (1)pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Modify Therapy/Monitor Closely. 200-800 mg/kg (2-8 mL/kg) every 3-4 weeks. Use Caution/Monitor. Fulminant symptoms may include general paleness, confusion or episodes of passing out. Elemental iron product this is a choice between three iron supplement products: Iron dextran 50 mg/mL, Iron sucrose 20 mg/mL and Ferric gluconate 12.5 mg/mL. Follow your doctor's directions carefully.Tell your doctor right away if you have any serious side effects, including: abdominal pain, chest pain, irregular heartbeat (arrhythmias), pressure in the chest, severe headache and blurred vision (hypertension), problems with your dialysis access site (graft).A very serious allergic reaction to this drug is unlikely, but get medical help right away if it occurs. Applies only to oral form of both agents. sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. Each mL contains 20 mg of elemental . Applies only to oral form of both agents. All Rights Reserved. Use Caution/Monitor. Please confirm that you would like to log out of Medscape. Avoid or Use Alternate Drug. It can be expressed in mg per ml. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet. Estimates the iron deficit in preparation for iron replacement based on patient weight and haemoglobin. No additional iron to replenish stores. Minor/Significance Unknown. Separate dosing of tetracyclines from these products. The prevention and treatment of iron deficiency is a major public health goal, especially in women, children, and individuals in low-income countries. provider for the most current information. Compare formulary status to other drugs in the same class. Access your plan list on any device mobile or desktop. World J Gastroenterol; 16(22): 27202725. nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. Minor/Significance Unknown. Your doctor will do laboratory tests to monitor your response. Your doctor will do laboratory tests to monitor your response. Ferric gluconate: 12.5 mg/mL. 2010;18(3). Applies only to oral form of both agents. Ganzoni AM. Burns DL, Mascioli EA, Bistrian BR. Venofer treatment may be repeated if iron deficiency reoccurs. Initial symptoms may include hypotension, syncope, unresponsiveness, cardiac/cardiorespiratory arrest. Intravenous iron replacement can take place as total dose (as in the case of iron-dextran or iron carboxymaltose) or as split dose (in the case of iron sucrose). Copyright(c) 2023 First Databank, Inc. FOR PATIENTS WEIGHING 50 kg OR MORE: Administer 1000 mg of Monoferric by intravenous infusion 20 minutes as a single dose 1. 4. Venofer and the Venofer logo are registered trademarks of Vifor (International) Inc., Switzerland. Give each dose as 750 mg for a total cumulative dose of 1500 mg of iron per course. Minor/Significance Unknown. Contact the applicable plan This medicine is sometimes given slowly, and the infusion can take up to 2.5 hours to complete. Applies only to oral form of both agents. 0.5 mg/kg (not to exceed 100 mg/dose) diluted to a concentration of 1 to 2 mg/mL in 0.9% sodium chloride IV over 5 to 60 minutes Administer every 4 weeks for 12 weeks Do not dilute to concentrations below 1 mg/mL Comments: Treatment may be repeated if necessary. INDICATIONS AND USAGE: Intravenous or intramuscular injections of INFeD are indicated for treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. Applies only to oral form of both agents. commonly, these are "non-preferred" brand drugs or specialty Intravenous iron-dextran: therapeutic and experimental possibilities [in German] Schweiz Med Wochenschr. Anemia; 2015: 763576. Med J Aust. Privacy Policy, Use 500 mg for adults and children 35 kg; use 15 mg/kg if <35 kg. commonly, these are "non-preferred" brand drugs. Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant women with parenteral iron products (such as Venofer) which may cause fetal bradycardia, especially during the second and third trimester. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Serious - Use Alternative (1)iron sucrose decreases levels of oxytetracycline by inhibition of GI absorption. Then enter the value of the Dosage and choose the unit of measurement from the drop-down menu. Use Caution/Monitor. Human studies not conducted. Applies only to oral form of both agents. Applies only to oral form of both agents. (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. Consult your pharmacist or local waste disposal company. Total dose iron infusion: safety and efficacy in predialysis patients. Each mL contains 20 mg of elemental iron. Applies only to oral form of both agents. iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. Monitor Closely (1)iron sucrose decreases levels of ibandronate by inhibition of GI absorption. If dose exceeds 20mg/kg it should be rounded down to 20mg/kg OR administration of the total dose has to be split and given 7 days apart. Use Caution/Monitor. Many people using this medication do not have serious side effects.Severe dizziness or fainting (hypotension) may occur while you are receiving IV iron. Applies only to oral form of both agents. Venofer (Iron Sucrose Injection) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Both the 200- and 300-mg doses of IV iron sucrose administered over 2 hours appear to be safe. The iron deficit estimation is based on the Ganzoni formula: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. The primary endpoint was the proportion of patients with . Your list will be saved and can be edited at any time. Iron deficiency can occur at any stage of life, due to physiological demands, for example, during pregnancy, childhood growth or prolonged periods of sickness. Monitor Closely (1)iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. Monitor Closely (1)iron sucrose decreases levels of penicillamine by inhibition of GI absorption. Use Caution/Monitor. Deferoxamine chelates iron. For patients weighing less than 50 kg (110 lb): Give Injectafer in two doses separated by at least 7 days. calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet Administration: I. Sodium ferric gluconate complex injection [ Ferrlecit ] [package insert] - Elemental iron: 12.5 mg/mL (5 mL). This website also contains material copyrighted by 3rd parties. Deferoxamine chelates iron. Immune system disorders: Anaphylactic-type reactions, angioedema, Nervous system disorders: Convulsions, collapse, light-headedness, loss-of-consciousness, Respiratory, thoracic and mediastinal disorders: Bronchospasm, dyspnea, Musculoskeletal and connective tissue disorders: Back pain, swelling of the joints, General disorders and administration site conditions: Hyperhidrosis, Published studies on intravenous iron sucrose treatment after first trimester of pregnancy not shown adverse maternal or fetal outcomes; available reports of intravenous iron sucrose use in pregnant women during first trimester are insufficient to assess risk of major birth defects and miscarriage; iron deficiency anemia during pregnancy should be treated because there are risks to mother and fetus associated with untreated iron deficiency anemia (IDA) in pregnancy; risks to fetus associated with maternal severe hypersensitivity reactions, Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant women with parenteral iron products which may cause fetal bradycardia, especially during second and third trimester, Iron sucrose is present in human milk, and available published reports following exposure to 100-300 mg intravenous iron sucrose have not reported adverse reactions in breastfed infants; there are no data on effects on milk production, Developmental and health benefits of breastfeeding should be considered, along with mothers clinical need for treatment and any potential adverse effects on breastfed child from therapy or from underlying maternal condition. For repletion treatment most patients may require a cumulative dose of 1000 mg of elemental iron administered over 8 dialysis sessions. iron sucrose increases levels of calcium gluconate by enhancing GI absorption. Avoid or Use Alternate Drug. Minor/Significance Unknown.iron sucrose increases levels of calcium acetate by enhancing GI absorption. Applies only to oral form of both agents. Dosing for patients who weigh 50 kg or more For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. Use Caution/Monitor. Applies only to oral form of both agents. iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. Alternatively the total dose may be calculated: Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x LBW + (0.26 x LBW) Based on: Desired Hb = the target Hb in g/dl. Consult your doctor before breast-feeding. Use Caution/Monitor.Minor (2)calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. Replacement of iron stores found in hemoglobin, myoglobin, and enzymes; works to transport oxygen via hemoglobin, Do not mix with other medications or add to parenteral nutrition solutions for IV infusion, Do not dilute to concentrations below 1 mg/mL, Add dose to 0.9% NaCl infusion bags (PVC or non-PVC); final concentrations range is 1-2 mg of elemental iron/mL, Visually inspect for particulate matter and discoloration prior to infusion, Stable for 7 days at controlled room temperature (25C). Patients diagnosed with iron deficiency are prescribed iron supplementation, either to replete body stores or to correct anemia. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. Before using, check this product visually for particles or discoloration. IDA diagnosis is based on full blood examination and on the serum ferritin level. Avoid or Use Alternate Drug. The normal ranges are: for males 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and for females 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). Venofer may cause clinically significant hypotension. DOSAGE AND ADMINISTRATION: The recommended dose of Feraheme is an initial 510 mg dose followed by a second 510 mg dose 3 to 8 days later. Excessive dosages of Venofer may lead to accumulation of iron in storage sites potentially leading to hemosiderosis. Monitor Closely (1)vonoprazan will decrease the level or effect of iron sucrose by inhibition of GI absorption. deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events. Applies only to oral form of both agents. Use alternatives if available. Most Use Caution/Monitor. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Calculation of the Total Iron Deficit Alternative equation, Iron Dextran Dosing Calculator (iron deficit), HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication, Pharmacosmos A/S, CosmoFer low molecular weight (Mw) iron dextran. iron sucrose, benazepril. Schweiz Med Wochenschr; 100(7):301-3. 2. . 1970; 100(7):301-3. concentration of elemental iron (mg/ml) in the product being used: This calculator will help pinpoint potential causes of anemia based on an automated flowchart approach. Applies only to oral form of both agents. There are four variables, all patient parameters, required in the iron deficiency calculator: The patients weight is used in the Ganzoni equation and also when establishing the iron stores. Applies only to oral form of both agents. Iron sucrose: 20 mg/mL. Applies only to oral form of both agents. Applies only to oral form of both agents. A: Generally acceptable. Patients measured hemoglobin can be input in g/dL or mmol/L. Fill in the calculator/tool with your values and/or your answer choices and press Calculate. 2022 American Regent, Inc.PP-VE-US-0016 (v6.0)1/2022. Venofer (iron sucrose) dose calculator | Calculosaurus.com Clinical calculators for obstetrics and gynaecology VTE risk assessment Calculator menu Venofer dose calculator Iron sucrose Not what you were looking for? iron sucrose decreases levels of minocycline by inhibition of GI absorption. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. Modify Therapy/Monitor Closely. iron sucrose decreases levels of levothyroxine by inhibition of GI absorption. Interaction only with oral iron administration. Medically reviewed by Drugs.com. Serious - Use Alternative (1)iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. Applies only to oral form of both agents. Coadministration of ciprofloxacin with multivalent cation-containing products may reduce the bioavailability of ciprofloxacin by 90%. Applies only to oral form of both agents. USES: This medicine is used to treat "iron-poor" blood (anemia) in people with long-term kidney disease. (3) Known hypersensitivity to Venofer. ------------------------------------------------------------------------- Iron Dextran Complex [ Infed ] Elemental iron: 50 mg of elemental iron per mL [2 mL] [package insert] BOXED WARNING: WARNING: RISK FOR ANAPHYLACTIC-TYPE REACTIONS Anaphylactic-type reactions, including fatalities, have followed the parenteral administration of iron dextran injection. Venofer (iron sucrose injection, USP) For Intravenous Use Only INDICATION AND USAGE Venofer (iron sucrose injection, USP) is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Minor (2)calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. After total replacement dose completed, need for ongoing IV doses should be re-assessed monthly. The dosage is expressed in terms of mg of elemental iron, with each mL of Feraheme containing 30 mg of elemental iron. Properly discard this product when it is expired or no longer needed. Drug class: Iron products. Venofer can be given as a maximum of 200mg not more than 3 times per week; doses must be 24 hours apart. Either increases effects of the other by pharmacodynamic synergism. The factor 2.4 is derived from the following assumptions: a) Blood volume 70 ml/kg of body weight ~7% of body weight b) Iron content of hemoglobin 0.34% Factor 2.4 = 0.0034 x 0.07 x 10000 (conversion for g/dL) Ganzoni AM. Administer Venofer early during the dialysis session (generally within the first hour). Administer on 5 different occasions over a 14 day period. Equations : Total body iron deficit (mg) = body weight (kg) x (target Hb - actual Hb in g/dL) x 2.4 + iron depot (mg)** [1, 2] Iron depot: 15 mg/kg for body weight less than 35 kg 500 mg for those with a body weight greater than or equal to 35 kg Ideal Body Weight (kg) =45.5 +2.3 * (height inches - 60 inches) [3] Baloxavir may bind to polyvalent cations resulting in decreased absorption. Minor (1)iron sucrose decreases levels of manganese by inhibition of GI absorption. commonly, these are "preferred" (on formulary) brand drugs. Minor/Significance Unknown. We have found the lower dose to be better tolerated in the second half of gestation.

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