Apply using a medium quality spray using a spray pressure of 2-3 bar. The Docket Facility telephone number is (703) 305-5805. In the rat reproduction study, reproductive toxicity was not observed, but decreased pup survival Start Printed Page 12742and decreased pup body weight/body-weight gain during lactation were observed above the limit dose with only reduced body weight and food consumption observed in the parental animals (>1,200 mg/kg/day). In 2013 and 2014 we evaluated the plant growth regulator trinexapac-ethyl, which is sold under the trade name Palisade. Therefore, based on the risk assessments and information described above, EPA concludes there is a reasonable certainty that no harm will result to the general population or to infants and children from aggregate exposure to trinexapac-ethyl residues. 0 Application of Palisade or Palisade plus Tilt increased grain yield at Chickasha and had no effect on grain yield at Stillwater or Perkins. documents in the last year, by the Fish and Wildlife Service Seed weight was generally inversely related to yield; trinexapac-ethyl treatments that produced the highest yield also had the lowest seed weight. (a) General. 02/28/2023, 828 documents in the last year, 287 Wheat lodging is not generally a widespread problem in Oklahoma, but it does occur. Internal Tracking Number: 605329 Substance Type: Chemical Substance Systematic Name: Cyclohexanecarboxylic acid, 4- (cyclopropylhydroxymethylene)-3,5-dioxo-, ethyl ester CAS Number: 95266-40-3 EPA Registry Name: Trinexapac-ethyl Molecular Weight: 252.27 Molecular Formula: C13H16O5 Additional Metadata Recommendations may change as further research is conducted and new information is obtained. Prevent further spillage or leakage if it is safe to do so. EPA may establish a tolerance that is different from a Codex MRL; however, FFDCA section 408(b)(4) requires that EPA explain the reasons for departing from the Codex level. Latest Registration Process: Registration Review . documents in the last year, 983 Further information about EPA's risk assessment and determination of safety can be found at http://www.regulations.gov in the document titled Trinexapac-ethyl. edition of the Federal Register. The method may be requested from: Chief, Analytical Chemistry Branch, Environmental Science Center, 701 Mapes Rd., Ft. Meade, MD 20755-5350; telephone number: (410) 305-2905; email address: residuemethods@epa.gov. These effects in the dog study were observed only at high doses (>357 mg/kg/day) and with chronic exposure, and no associated neurological signs or other neuropathology were observed. The petition requested that 40 CFR part 180.662 be amended by establishing tolerances for residues of the herbicide trinexapac-ethyl, (4-(cyclopropyl-a-hydroxy-methylene)-3,5-dioxo-cyclohexanecarboxylic acid ethyl ester), and its primary metabolite CGA-179500 in or on sugarcane, cane at 1.5 parts per million (ppm) and sugarcane, molasses at 5.0 ppm. Acute dietary risks are below the Agency's level of concern: 2.5% of the acute population adjusted dose (aPAD) for females 13 to 49 years old, the population group of concern. 2023 United States Golf Association. Additionally, T-NEX is the perfect pre-stress conditioning choice for the coming season. For complete information about, and access to, our official publications that agencies use to create their documents. include documents scheduled for later issues, at the request Because these products primarily affect cell elongation and not division, the number of new cells is only slightly reduced while their ability to elongate is significantly altered. Acute risk. Process Trigger: First Food Use Registration Review Case: TRINEXAPAC-ETHYL , Case #7228: Substance Information . Trinexapac-ethyl is a plant growth regulator that inhibits the formation of gibberellic acid and is used as an anti-lodging agent. These can be useful The Codex has established an MRL for trinexapac-ethyl in or on sugarcane at 0.5 ppm. UF, Residential LOC for MOE = 100 Since tolerances and exemptions that are established on the basis of a petition under section 408(d) of FFDCA, such as the tolerance in this final rule, do not require the issuance of a proposed rule, the requirements of the Regulatory Flexibility Act (RFA) (5 U.S.C. Compliance with the tolerance levels specified below is to be determined by measuring only the free and conjugated forms of both trinexapac-ethyl, ethyl 4-(cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylate and trinexapac, 4-(cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylic acid, calculated as the stoichiometric equivalent of trinexapac-ethyl, in or on the commodity. EPA assessed residential exposure with the assumption that homeowner handlers wear shorts, short-sleeved shirts, socks, and shoes, and that they complete all tasks associated with the use of a pesticide product including mixing/loading, if needed, as well as the application. Trinexapac-ethyl is approved for use on cereal crops such as barley, durum wheat, oats, rye, triticale and wheat as well as grassland, amenity turf and managed turf. A Rule by the Environmental Protection Agency on 11/04/2020. menu. The Public Inspection page may also Statutory and Executive Order Reviews, PART 180TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD, https://www.federalregister.gov/d/2020-23040, MODS: Government Publishing Office metadata, http://www.ecfr.gov/cgi-bin/text-idx?&c=ecfr&tpl=/ecfrbrowse/Title40/40tab_02.tpl, http://www.epa.gov/dockets/contacts.html. has no substantive legal effect. Trinexapac-ethyl 25%ec, 250g/l ec from Chinese Other supplier - Meorient Import & Export Co.LTD on tradechina.com . Similarly, EPA does not believe that the non-dietary residential exposures are underestimated because they are based on the conservative assumptions of EPA's Draft Standard Operating Procedures (SOPs) for Residential Exposure Assessments (December 1997), and updates contained in the Science Advisory Council Policy 12 (February 2001) as well as the uses specified in the proposed labels. Furthermore, similar lesions were not observed in the rat or mouse following subchronic or chronic dietary exposure, and there was no other evidence in any species tested to indicate a neurotoxicity potential. | Home | Index of common names | Pesticideclassification| SiteMap| from 47 agencies. We conducteda separate trial evaluating Palisade in drought stress environments that was partially funded by Syngenta. documents in the last year, 1408 has no substantive legal effect. the current document as it appeared on Public Inspection on Uncertainty/safety factors (U/SF) are used in conjunction with the POD to calculate a safe exposure levelgenerally referred to as a population-adjusted dose (PAD) or a reference dose (RfD)and a safe margin of exposure (MOE). Call a poison control center or doctor for treatment advice If in eyes Hold eye open and rinse slowly and gently with water for 15-20 minutes. This regulation establishes tolerances for residues of trinexapac-ethyl in or on multiple commodities which are identified and discussed later in this document. Establish reliable relationship between buyers and suppliers through our matching services and find new business opportunities through various online exhibitions. Lodging at head emergence, for example, can cause as little as 30 or as much as 80% yield reduction. This final rule does not contain any information collections subject to OMB approval under the Paperwork Reduction Act (PRA), 44 U.S.C. That is, a plant growth regulator will not make a lodging prone variety stand like one with excellent straw strength, rather they will make it less prone to lodging relative to the same variety non treated. Table 1Summary of Toxicological Doses and Endpoints for Trinexapac-ethyl for Use in Human Health Risk Assessment. . Application of Palisade or Palisade plus Tilt increased grain yield at Chickasha and had no effect on grain yield at Stillwater or Perkins in 2013. Each document posted on the site includes a link to the While application of Palisade resulted in numeric reductions in plant height at Chickasha and Stillwater, differences among treatments were not statistically significant. should verify the contents of the documents against a final, official name for 4-(cyclopropyl--hydroxymethylene)-3,5-dioxo-cyclohexanecarboxylic acid ethyl ester . Name: Trinexapac-ethyl: Trinexapac-ethyl; 4- (Cyclopropyl-alpha-hydroxymethylene)-3,5-dioxo-cyclohexanecarboxylic acid ethyl ester; Ethyl 4-cyclopropyl (hydroxy)methylene-3,5-dioxocyclohexanecarboxylate Contacts. ChemSpider ID 83439. Molecular Formula CHO. on FederalRegister.gov Palisade did not affect lodging at Perkins. There are no tolerances currently established for trinexapac-ethyl. Schedule for Beginning Reviews. Document page views are updated periodically throughout the day and are cumulative counts for this document. 2. Further information regarding EPA standard assumptions and generic inputs for residential exposures may be found at http://www.epa.gov/pesticides/trac/science/trac6a05.pdf. The President of the United States communicates information on holidays, commemorations, special observances, trade, and policy through Proclamations. on FederalRegister.gov We conducted the trial at Stillwater (Irr), Perkins (Irr), and Chickasha (Non-Irr). Although listed in the index, some information is not publicly available, e.g., Confidential Business Information (CBI) or other information whose disclosure is restricted by statute. As such, the Agency has determined that this action will not have a substantial direct effect on States or Tribal Governments, on the relationship between the National Government and the States or Tribal Governments, or on the distribution of power and responsibilities among the various levels of government or between the Federal Government and Indian Tribes. ), do not apply. on EPA is setting different levels than were proposed based on EPA's analysis of the field trial data using the Organization for Economic Cooperation and Development tolerance calculation procedures. EPA is revising the tolerance expression to include the free and conjugated forms of the parent (trinexapac-ethyl) and acid. Trinexapac-ethyl is a synthetic plant growth regulator that is derived from cyclohexanecarboxylate. daily Federal Register on FederalRegister.gov will remain an unofficial The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. Our results are consistent with other wheat plant growth regulator research, which has reported similar variation in response among sites and years. For complete information about, and access to, our official publications hb```paB K>K:5R e-b endstream endobj 1017 0 obj <>/Metadata 25 0 R/Pages 1014 0 R/StructTreeRoot 31 0 R/Type/Catalog>> endobj 1018 0 obj <>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/StructParents 0/Tabs/S/Type/Page>> endobj 1019 0 obj <>stream Home; Product . error_outlineEmergency Number01484 538 444. the official SGML-based PDF version on govinfo.gov, those relying on it for Information about this document as published in the Federal Register. In the mouse, there was no evidence of carcinogenicity. Quick Resources. In evaluating dietary exposure to trinexapac-ethyl, EPA considered exposure under the petitioned-for tolerances. In addition, this action does not impose any enforceable duty or contain any unfunded mandate as described under Title II of the Unfunded Mandates Reform Act (UMRA) (2 U.S.C. The extract was directly injected into the HPLC system. Acute dietary (General population including infants and children), No appropriate endpoint for the general population including infants and children, Chronic RfD = 0.32 mg/kg/day cPAD = 0.32 mg/kg/day. This final rule establishes tolerances under section 408(d) of FFDCA in response to petitions submitted to the Agency. Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). In 2013 we evaluated the plant growth regulator trinexapac-ethyl, which is sold under the trade name Palisade. The docket for this action, identified by docket identification (ID) number EPA-HQ-OPP-2020-0046, is available at http://www.regulations.gov or at the Office of Pesticide Programs Regulatory Public Docket (OPP Docket) in the Environmental Protection Agency Docket Center (EPA/DC), West William Jefferson Clinton Bldg., Rm. Rolston, C.J. Based upon review of the data supporting the petition, EPA has revised most of the proposed tolerance levels, added tolerances for hog fat and meat, and deleted the proposed tolerance for cattle kidney. Therefore, short-term dermal post-application exposures and risks were also assessed for trinexapac-ethyl. 3501 et seq. Trinexapac-ethyl 25%ec, 250g/l ec from Chinese Other supplier - Meorient Import & Export Co.LTD on tradechina.com. Any trinexapac-ethyl that hits the soil is lost. Trinexepac-ethyl Brand: PrimeraOne Downloads: Label , SDS Containing the same active ingreedient as PRIMO MAXX; PrimeraONE Trinexapac-Ethyl will make your course greener and reduce the number of mowings, saving labor, fuel, and time. What are the uses of Trinexapac-ethyl ? Therefore, 40 CFR chapter I is amended as follows: 1. Established in October, 2003, Jiafu International Trade Co., Ltd. is a specialized international trade company based on ISO9001 quality system strictly. developer tools pages. EPA has established a docket for this action under docket identification (ID) number EPA-HQ-OPP-2010-0524. Schedule for Beginning Reviews. documents in the last year, 83 The objective of this work was to evaluate the effect of trinexapac-ethyl and nitrogen doses on the agronomic performance and grain yield of three wheat cultivars. Action: Plant growth . In this section you will find the primary documents produced to support the registration and review processes. Trinexapac-ethyl CAS 95266-40-3 WIKI information includes physical and chemical properties, USES, security data, NMR spectroscopy, computational chemical data and more. 5. documents in the last year, 121 =;Xb`0[,o DUv LOC for MOE = 100. Because the acute and chronic dietary exposure estimates were based on several conservative assumptions (100% of crops treated with residues present at tolerance levels, default processing factors and screening level drinking water estimates), EPA is confident that the dietary exposure assessments do not underestimate risk to the general U.S. population and various population subgroups. Leakage if it is safe to do so no effect on grain yield at Stillwater ( )... By the Environmental Protection Agency on 11/04/2020 of the documents against a final, name. -- hydroxymethylene ) -3,5-dioxo-cyclohexanecarboxylic acid ethyl ester: trinexapac-ethyl ; 4- ( cyclopropyl -- hydroxymethylene ) -3,5-dioxo-cyclohexanecarboxylic acid ester. 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